Mysimba (naltrexone / bupropion) 112 tablets for weight loss

Buy Mysimba Online in the UK & US

Are Mysimba weight loss pills suitable for me?

Mysimba (naltrexone / bupropion) is especially well-suited for people who feel hungry even though they’ve eaten or who have cravings for eating particular foods or eating at particular times, usually in the evening.

This includes people who have lost weight or have tried to lose weight before with a calorie-controlled diet and more exercise.

This type of eating is called Emotional Eating, and it is a real and medically recognised cause of weight gain.

People who eat this way are often busy or stressed and have little time for themselves. They may not have proper mealtime routines and end up eating on the go or while distracted doing something else, like working or looking after children.

They may think of themselves as “snackers” or “grazers” and struggle to be consistent with a diet or exercise routine because life gets in the way.

To be able to use Mysimba (naltrexone / bupropion) safely, you must have a starting body mass index (BMI) of 30 or 27 with certain other health conditions.

Mysimba could also be a good option for people who want to use Wegovy or Mounjaro but don’t like the idea of using an injection.

See our dedicated article to learn more about weight loss injections.

Using the BMI weight loss calculator

A body mass index, or BMI, is a calculation that shows how heavy a person is compared to how tall they are.

The best way to find your BMI is to use a special online calculator like this one designed by the NHS.

You may be able to use Mysimba if your BMI number is above 30 or if it is above 27 and you have other health conditions like

• High blood pressure
• Heart disease
• Obstructive sleep apnoea
• High cholesterol
• Osteoarthritis
• Depression
• Polycystic ovary syndrome

How does Mysimba work?

Mysimba (naltrexone / bupropion) contains two different medicines in one tablet. These medicines are called Bupropion and Naltrexone, and they do slightly different things to help you lose weight.

Bupropion and Naltrexone work together as a team to reduce hunger and control food cravings.

Hunger is when our brain tells us that we need food for energy and that any food will do.

A craving is when our brain tells us that we want a specific food or type of food, even if we’re not hungry.

Controlling hunger and cravings means eating smaller portion sizes at mealtimes and not wanting to snack on food that may have previously caused you to gain weight.

Both Buproprion and Naltrexone have been used for more than 30 years to treat other conditions, including helping people to stop smoking and other addictions by controlling those cravings.

Mysimba is not a laxative or a stimulant.

How long does Mysimba take to work?

A successful weight loss journey takes time, especially if you want to keep the weight off after you stop treatment.

In clinical studies, the most significant weight loss was seen after 4 months (16 weeks) of taking Mysimba as prescribed.

How long does Mysimba last?

Your first box of 112 Mysimba tablets will last just over 5 weeks (38 days). This is because the number of tablets you take every day is gradually increased for the first 3 weeks.

After the first 38 days, a box of tablets will last 4 weeks (28 days).

How effective is Mysimba?

Three different clinical studies of over 2000 people showed how those taking Mysimba, along with diet and exercise, lost 2-4 times more weight over 1 year than with diet and exercise alone and kept it off.

Who should not use Mysimba?

Mysimba is not for everyone. Do NOT take Mysimba if you:

• have uncontrolled high blood pressure
• have or have had seizures
• use other medicines that contain bupropion, such as Zyban
• have or have had an eating disorder called anorexia (eating very little) or bulimia (eating and then being sick to avoid gaining weight)
• are dependent on opioid pain medicines, such as Codeine, Morphine or Fentanyl
• use medicines to help stop taking opioids, or are in opiate withdrawal
• drink a lot of alcohol or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti-seizure medicines
• are taking medicines called monoamine oxidase inhibitors (MAOIs). Ask us if you are not sure if you take an MAOI. Do NOT start Mysimba until you have stopped taking your MAOI for at least 14 days
• are allergic to Buproprion, Naltrexone or any of the ingredients in Mysimba. See the patient information leaflet for a complete list of ingredients

Can I get Mysimba from my GP?

It’s very unlikely. Mysimba has not been used by the NHS since 2017. This is not because it doesn’t work or because it isn’t safe.

It’s because it is expensive, more so than other medicines that can help with weight loss, like Orlistat, Wegovy or Mounjaro.

Mysimba Dosage

We will clearly explain the dose of Mysimba on the medicine label. You should always follow our instructions carefully.

When you start using Mysimba, you have to take the tablets in a certain way, where the number of tablets you take every day changes each week.

How to take Mysimba

Week 1

One tablet a day, taken in the morning

Week 2

Two tablets a day, one in the morning and one in the evening

Week 3

Three tablets a day, two in the morning and one in the evening

Week 4 and onward

Four tablets a day, two in the morning and two in the evening. This is the maximum dose you should take.

After week 4, you should continue taking two tablets in the morning and two tablets in the evening.

Take Mysimba (naltrexone / bupropion) contains two different medicines in one tablet. These medicines are called Bupropion and Naltrexone with food and swallow the tablets whole with a glass of water.

Never take more than 4 tablets in one day.

Mysimba side effects

All medicines can cause side effects, although not everyone will get them.

Mysimba’s side effects have been safely studied in thousands of people. They are most likely to happen in the first four weeks of treatment before lessening or going away.

The most common side effects affect more than 1 in 10 people who use this medicine.

Not everyone who experiences a side effect will get all of them.

These include

• Nausea
• Constipation
• Headache
• Vomiting
• Dizziness
• Trouble sleeping (insomnia)
• Dry mouth
• Diarrhoea

Drinking plenty of water during the day and eating fresh foods like fruits and vegetables can help with nausea, constipation, headache and dry mouth, and are also good for weight loss.

Fewer than 1 in 10 but more than 1 in 100 people who use Mysimba will experience a common side effect. Not every person who gets a side effect will experience all of them.

These include

• Anxiety
• Insomnia (difficulty sleeping)
• Tremors (feeling shaky)
• Dysgeusia (a bad or unpleasant taste in the mouth)
• Lethargy (tiredness)
• Somnolence (sleepiness)
• Tinnitus (ringing in the ears)
• Palpitations (irregular heart beat) or a higher-than-usual heart rate
• Flushing or suddenly feeling hot
• Pain or aches in the tummy
• Hyperhidrosis (sweating more than usual)
• Pruritus (itchy skin)
• Alopecia (hair falling out)
• Rash
• Feeling jittery
• Feeling irritable

Read the Mysimba patient information leaflet for a complete list of all possible side effects.

Serious side effects

If you experience any of these serious side effects, seek emergency medical attention immediately by calling 999 or going to your nearest hospital emergency department.

• Thoughts about suicide or hurting yourself, or other distressing thoughts
• Fits or seizures, loss of consciousness (fainting)
• Symptoms of the conditions Stevens-Johnson Syndrome or Erythema Multiforme, e.g. itchy spots that appear red on white skin, which usually start on the arms and legs, severe blisters, bleeding on the lips, eyes, mouth, nose, or genitals
• Symptoms of the condition Rhabdomyolysis, e.g. severe muscle cramps, muscle pain, muscle weakness. This can be in any part of the body
• Symptoms of a severe allergic reaction, e.g. difficulty swallowing or breathing, pain in the muscles or joints, itching, hives, a rash that appears red on white skin, dizziness, fever, swelling of the face, tongue, mouth or throat
• Increases in blood pressure or heart rate
• Symptoms of liver damage or hepatitis e.g. stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness
• Manic episodes
• Problems with your vision (symptoms of angle-closure glaucoma include eye pain, changes in vision, swelling, or redness in or around the eye)
• Low blood sugar (hypoglycemia) in people with type 2 diabetes mellitus who also take medicines to treat diabetes (such as insulin or sulfonylureas)